The HHS Office of Minority Health (OMH) anticipates funding two cooperative agreements to support a Center for Indigenous Innovation and Health Equity (CIIHE). The CIIHE will support efforts, including research, education, service, and policy development, to advance sustainable solutions that address indigenous health disparities and advance health equity in American Indian and Alaska Native (AI/AN) and Native Hawaiian and Pacific Islander (NHPI) populations. Applicants will be required to address only one of the two focus populations per application. One applicant may submit more than one application, but each application must focus on only one population. The CIIHE will operate as a single initiative through two cooperative agreements – one with a focus on AI/AN populations and one with a focus on NHPI populations. Under the cooperative agreements, OMH will have substantial involvement in identifying priority areas to focus the CIIHE’s efforts such as the role of nutrition, food security, and physical activity in indigenous health disparities. OMH will facilitate the coordination and collaboration of project activities between the cooperative agreements to support seamless program implementation. Recipients will establish, convene, and manage a joint CIIHE advisory board.