The purpose of the Health Careers Opportunity Program (HCOP) is to assist individuals from disadvantaged backgrounds to enter a health profession through the development of academies that will support and guide them through the educational pipeline. In response to virtual alternatives created during the pandemic, HCOPs will explore cutting-edge technology, such as data analytics, artificial intelligence and machine learning to advance health equity and population health. The National HCOP Academics focus on: 1) promoting the recruitment of qualified individuals from economically or educationally disadvantaged backgrounds into health professions, including allied health programs; 2) improving retention, matriculation and graduation rates by implementing tailored enrichment programs designed to address the academic and social needs of economically or educationally disadvantaged students; and 3) providing opportunities for community-based health professions training in primary care settings, emphasizing experiences in rural and underserved communities.