Commercial tobacco use remains the leading preventable cause of disease and death in the United States. More than half of people who smoke attempt to quit each year, but fewer than one in ten succeed. Proven cessation treatments that include individual, group, and telephone cessation counseling, seven Food and Drug Administration (FDA)-approved cessation medications, and web and text based interventions exist, but are underutilized. The Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health is announcing the opportunity to apply for funds for a competitive, non-research cooperative agreement aimed at building the capacity of state and territorial tobacco control programs and their partners to translate the science of tobacco cessation into public health interventions. These interventions are aimed at increasing the number of people who make an attempt to quit using tobacco products and who succeed in quitting. Training and technical assistance delivered through this funding will prioritize interventions that reach population groups disproportionately impacted by tobacco use and cessation-related disparities and be provided around the three goal areas for tobacco control programs’ cessation activities described in the 2014 edition of CDC’s Best Practices for Comprehensive Tobacco Control Programs. These include 1) Promoting health systems change to integrate evidence-based tobacco dependence treatment into routine clinical care; 2) Improving insurance coverage of evidence-based cessation treatments and increasing use of these treatments; and 3) Supporting state quitline capacity. This funding opportunity is projected to have a 60-month (5-year) period of performance with five 12-month budget periods. Each award (3 awards) is projected to have a 12-month budget of $300,000.