The DOE SC program in Isotope R&D and Production, referred to as the DOE Isotope Program (DOE IP), announces its interest in receiving applications for Research and Development (R&D) on high priority topics, related to increasing availability of radioactive and stable isotopes in short supply. The proposed R&D should generate data and/or technology complementary to, and not duplicative of, those that exist or are currently funded. Applications incorporating effective ways to diversify and train the next generation of personnel with essential knowledge and skills related to the production, processing, and purification of radioactive and enriched stable isotopes are strongly encouraged.